| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5374725 | Chemical Physics | 2011 | 14 Pages |
Abstract
⺠The phosphonate prodrug studied offers an excellent potential as alternative to AZT. ⺠The 84 most energetically favourable conformers were identified by DFT methods. ⺠The increment in the ring puckering produces a higher flexibility than in AZT. ⺠The high charge on the oxygen's chain could explain the high activity of this prodrug. ⺠The phosphonate chain has little influence in the charge distribution on the rings.
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Authors
A. Tamara Molina, M. Alcolea Palafox,