| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5374874 | Chemical Physics | 2010 | 7 Pages |
Abstract
The exocyclic carbonyl compound pyren-1-carboxyaldehyde, (1-PyCHO), binds to the ctDNA in an intercalative mode. Two possible angular orientations for intercalation into base-pairs are possible. Induced circular dichroism measurements indicate that the intercalation orientation of 1-PyCHO into DNA could be heterogeneous, that is, multiple binding orientations of the pyren-1-carboxyaldehyde must be involved.
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Authors
E. Grueso, R. Prado-Gotor,