Editor's ChoiceHadamard-encoded localized high-resolution NMR spectroscopy via intermolecular double-quantum coherences

•A pulse sequence is proposed for localized high-resolution NMR spectra.•Intermolecular double-quantum coherence and Hadamard encoding are utilized.•High-resolution spectral information can be retrieved in inhomogeneous fields.•The proposed method facilitates analyses of heterogeneous chemical systems.

A scheme based on Hadamard encoding and intermolecular double-quantum coherences is designed to obtain localized one-dimensional high-resolution NMR spectra in inhomogeneous fields. Brief theoretical derivation was performed to illuminate its principle. Experiments were carried out on phantom solution and biological tissues to verify its effectiveness in yielding useful spectral information and efficiency in suppressing solvent signal even when the field inhomogeneity is sufficiently severe to erase almost all spectral information. This sequence may provide a promising way for analyzing heterogeneous biological tissues and chemical systems.

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