Solvation free energies in [bmim]-based ionic liquids: Anion effect toward solvation of amino acid side chain analogues

- Calculated solvation free energies in water were highly correlated with reported experimental and simulation data.
- RTILs showed lower solvation free energy than water for most of the analogues.
- RTILs exhibited the capabilities of solvating molecules that were immiscible in water.
- An order of the effect of RTIL anions toward solvation of small molecules was established.
- The physicochemical properties of the solvents and solutes were related to the solvation thermodynamics investigated.