| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5382507 | Chemical Physics Letters | 2013 | 5 Pages |
Abstract
⺠Trehalose offsets the denaturing activity of urea. ⺠The N-state is stabilized by the decrease in solvent-excluded volume. ⺠The magnitude of the latter depends upon the aqueous solution density. ⺠Addition of trehalose and urea leads to a density increase. ⺠The latter offsets the urea energetic attractions with protein surface.
Related Topics
Physical Sciences and Engineering
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Physical and Theoretical Chemistry
Authors
Giuseppe Graziano,