Article ID Journal Published Year Pages File Type
5384820 Chemical Physics Letters 2010 5 Pages PDF
Abstract
► Spectral properties of indomethacin can sense solvent clusters in mixtures of 1-propanol-water. ► The drug forms fluorescent complex with alcohol self-association clusters at <40-60 wt. % water. ► It forms non-fluorescent complex with hydrogen-bonded water clusters at >40-60 wt. % water. ► Increasing water converts drug from fluorescent to non-fluorescent complex. ► This conversion makes the drug a sensor for microheterogeneity in alcohol-water mixtures.
Related Topics
Physical Sciences and Engineering Chemistry Physical and Theoretical Chemistry
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