Dissociation of DNA-polycation complexes by polyanions and polyampholytes

A diblocked polyampholyte exhibits the greatest tendency to bridge a DNA and a polycation. Consequently, its distribution at near θc = π is greater than other polyions, where θc = π denotes the condition when a polyampholyte (or a polyanion) is situated in the middle between a polycation and a DNA. As chain, architecture is changed to alternating polyampholyte and polyanion, but keeps the magnitude of monomer charges fixed, electrostatic bridging is weakened due to their weak dipolar interactions.