Molecular dynamics of solid furosemide (4-chloro-2-furfurylamino-5-sulfamoyl-benzoic acid) studied by NMR and DFT methods

Analysis of the second moment reductions M2, T1 minima and the activation energies found from the temperature dependencies of T1, indicates that the relaxation mechanism involves three types of motions: I - proton transfer, Arrhenius type and quantum tunnelling, II - a jumps of -NH2 and III - a quasi isotropic tumbling.