Strain energy in enzyme-substrate binding: An energetic insight into the flexibility versus rigidity of enzyme active site

Article ID	Journal	Published Year	Pages	File Type
5394630	Computational and Theoretical Chemistry	2012	7 Pages	PDF

Abstract

âº A mixed scheme is used to dissect energy components in enzyme-substrate binding. âº A good agreement of calculated with experimental binding energies is observed. âº Strain energy is responsible for the specificity of enzyme-substrate recognition. âº Enzyme active site possesses significant rigidity and also some flexibility.

Keywords

Enzyme Conformational change active site Substrate Strain energy

Related Topics

Physical Sciences and Engineering Chemistry Physical and Theoretical Chemistry

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Strain energy in enzyme-substrate binding: An energetic insight into the flexibility versus rigidity of enzyme active site

Authors

Xinchun Guo, Deyong He, Ling Huang, Limin Liu, Lijun Liu, Huijuan Yang,