Automated determination of Rifamycins making use of MPA-CdTe quantum dots

Under the optimized conditions, the relationship between the fluorescence intensity of the quantum dots and rifampicin or rifaximin concentrations were linear in the range of 5-80 and 3-40 µg mL−1, with a detection limit of 1.5 and 1.0 µg mL−1, respectively. Relative standard deviations (RSD) lower than 3% were observed in all cases. A sample throughput of 70 determinations per hour and good recoveries were also achieved. The proposed method was satisfactorily applied to the determination of rifamycins in pharmaceutical formulations and human urine.