Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5400344 | Journal of Luminescence | 2014 | 7 Pages |
Abstract
Fluorescence spectral properties of a series of novel benzanthrone derivatives have been explored in lipid bilayers composed of zwitterionic lipid phosphatidylcholine (PC) and its mixtures with cholesterol (Chol) and anionic phospholipid cardiolipin (CL). Analysis of partition coefficients showed that all the examined compounds possess rather high lipid-associating ability, with the amidino derivatives exhibiting stronger membrane partitioning compared with the aminobenzanthrones. To understand how benzanthrone partition properties correlate with their structure, quantitative structure property relationship (QSPR) analysis was performed involving a range of quantum chemical molecular descriptors.
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Authors
Olga Zhytniakivska, Valeriya Trusova, Galyna Gorbenko, Elena Kirilova, Inta Kalnina, Georgiy Kirilov, Paavo Kinnunen,