Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5401110 | Journal of Luminescence | 2012 | 4 Pages |
Abstract
⺠DNA binding studies of the triterpenoid derivative, cholesterol, N,N-Bis(3β-acetoxy-5α-cholest-6-yl-idene)hydrazine. ⺠The ligand binds to DNA through hydrophobic interaction with Kb value found to be 4.7Ã103 Mâ1. ⺠DNA is probably cleaved by an other than oxidative mechanism, possibly by a discernable hydrolytic pathway. ⺠In the presence of major and minor groove binding agents, the (L) prefers major groove binding of the DNA.
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Authors
Zishan Tabassum, Mohd Muddassir, Othman Sulaiman, Farukh Arjmand,