| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5401327 | Journal of Luminescence | 2012 | 8 Pages |
Abstract
⺠Novel Zn(II) complex 1 bearing bioactive glycyl glycine and sulfasalazine ligand scaffold. ⺠Cleavage activity of 1 was enhanced in presence of activators: H2O2>MPA>GSH>Asc. ⺠Complex 1 recognize minor groove as depicted in the cleavage pattern and molecular docking. ⺠Complex 1 cleaves pBR322 DNA via hydrolytic mechanism and validated by T4 DNA ligase experiments.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Sartaj Tabassum, Waddhaah M. Al-Asbahy, Mohd. Afzal, Manal shamsi, Farukh Arjmand,