Evaluating the use of a continuous approximation for model-based quantification of pulsed chemical exchange saturation transfer (CEST)

► Quantitative model-based analyses (QMAs) were performed on a pulsed CEST experiment. ► Important fitted model parameters (P) using different methods were compared. ► Discretization method (slow) could fit the experimental data with smaller error. ► But insignificant difference was found for P using continuous approximation (fast). ► Continuous approximation can be used for QMA in amide proton transfer imaging.