Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5406531 | Journal of Magnetic Resonance | 2010 | 7 Pages |
Abstract
A new concept of Variable Field Proton-Electron Double-Resonance Imaging (VF PEDRI) is proposed. This allows for functional mapping using specifically designed paramagnetic probes (e.g. oxygen or pH mapping) with MRI high quality spatial resolution and short acquisition time. Studies performed at 200 G field MRI with phantoms show that a pH map of the sample can be extracted using only two PEDRI images acquired in 140 s at pre-selected EPR excitation fields providing pH resolution of 0.1 pH units and a spatial resolution of 1.25Â mm. Note that while concept of functional VF PEDRI was demonstrated using the pH probe, it can be applied for studies of other biologically relevant parameters of the medium such as redox state, concentrations of oxygen or glutathione using specifically designed EPR probes.
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Authors
Valery V. Khramtsov, George L. Caia, Keerthi Shet, Eric Kesselring, Sergey Petryakov, Jay L. Zweier, Alexandre Samouilov,