Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5407447 | Journal of Magnetic Resonance | 2007 | 8 Pages |
Abstract
A double Pulsed Gradient Spin Echo (d-PGSE) MR experiment was used to measure and assess the degree of local diffusion anisotropy in brain gray matter, and in a novel “gray matter” phantom that consists of randomly oriented tubes filled with water. In both samples, isotropic diffusion was observed at a macroscopic scale while anisotropic diffusion was observed at a microscopic scale, however, the nature of the resulting echo attenuation profiles were qualitatively different. Gray matter, which contains multiple cell types and fibers, exhibits a more complicated echo attenuation profile than the phantom. Since microscopic anisotropy was observed in both samples in the low q regime comparable to that achievable in clinical scanner, it may offer a new potential contrast mechanism for characterizing gray matter microstructure in medical and biological applications.
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Authors
M.E. Komlosh, F. Horkay, R.Z. Freidlin, U. Nevo, Y. Assaf, P.J. Basser,