Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5407471 | Journal of Magnetic Resonance | 2007 | 12 Pages |
Abstract
Excitation sculpting, a general method to suppress unwanted magnetization while controlling the phase of the retained signal [T.L. Hwang, A.J. Shaka, Water suppression that works. Excitation sculpting using arbitrary waveforms and pulsed field gradients, J. Magn. Reson. Ser. A 112 (1995) 275-279] is a highly effective method of water suppression for both biological and small molecule NMR spectroscopy. In excitation sculpting, a double pulsed field gradient spin echo forms the core of the sequence and pairing a low-power soft 180°(âx) pulse with a high-power 180°(x) all resonances except the water are flipped and retained, while the water peak is attenuated. By replacing the hard 180° pulse in the double echo with a new phase-alternating composite pulse, broadband and adjustable excitation of large bandwidths with simultaneous high water suppression is obtained. This “Solvent-Optimized Gradient-Gradient Spectroscopy” (SOGGY) sequence is a reliable workhorse method for a wide range of practical situations in NMR spectroscopy, optimizing both solute sensitivity and water suppression.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Bao D. Nguyen, Xi Meng, Kevin J. Donovan, A.J. Shaka,