Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5407475 | Journal of Magnetic Resonance | 2007 | 7 Pages |
Abstract
A new 2D NMR experiment, HAT HMBC, that is a hybrid of H2BC and HMBC aims at establishing two-bond correlations absent in H2BC spectra because of vanishing 3JHH coupling constants. The basic idea is to create an additional Ï phase difference in the multiplet structure in HMBC peaks with respect to the n+1JHH coupling constant between the proton(s) attached to a 13C and a 1H separated by n bonds. Thus HMBC peaks associated with small JHH will be the most attenuated in a HAT HMBC spectrum in comparison to a regular HMBC spectrum, i.e. peaks associated with n+1JHH and nJCH will for n > 2 usually be strongly attenuated. The HAT HMBC pulse sequences contain the same number of pulses as regular HMBC and are only a few milliseconds longer.
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Authors
Andrew J. Benie, Ole W. Sørensen,