Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5407800 | Journal of Magnetic Resonance | 2006 | 6 Pages |
Abstract
Selective 1D TOCSY and NOESY experiments are widely used for structure determination. However, they often give distorted peak shapes owing to coherence transfer though zero-quantum coherence (ZQ) which cannot be suppressed by conventional phase cycling or pulse-field gradients. This paper demonstrates that ZQ contributions can be removed from selective 1D spectra by introducing a ZQ evolution time, as previously demonstrated for 2D NOESY spectra by Wang et al. [A three-dimensional method for the separation of zero-quantum coherence and NOE in NOESY spectra, J. Magn. Reson. A 102 (1993) 116-121]. This approach is simple to implement and robust, and is not demanding of spectrometer hardware. Using a new approach to phase cycling described here, spectra can be acquired in a similar time to spectra without a ZQ evolution time.
Related Topics
Physical Sciences and Engineering
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Authors
Peter W.A. Howe,