Solubility and solution thermodynamics of Raspberry Ketone in pure organic solvents and binary solvent mixtures from TÂ =Â (293.15 to 333.15) K

The target of this work is to measure and correlate the solubility of Raspberry Ketone, and obtain the thermodynamic parameters simultaneously. In this study, the solubility of Raspberry Ketone in nine mono-solvents, including ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetic acid, methyl acetate, ethyl acetate, acetone, and binary mixtures of ethanol + acetone (the mass fraction of ethanol varied from 0.1 to 0.9, in intervals of 0.1) was measured at (293.15 to 333.15) K in atmospheric pressure by shake-flask method. The solubility of Raspberry Ketone both in mono- solvents and mixtures increased as the temperature increased. The deliquescent rules can be acquired by using modified Apelblat equation, van't Hoff equation, λh equation, Wilson model, Non-Random Two Liquid (NRTL) model, Universal Quasi-Chemical (UNIQUAC) Model and modified Jouyban-Acree model. The experimental data show highly conformance with the calculated data which obtain from all the selected models. Consequently, the solubility results of this study would be useful in purification, crystallization, recrystallization and a new synthetic route design of Raspberry Ketone.