Construction of a water-soluble form of amino acid C-methylcalix[4]resorcinarene

This study depicts the construction of a water-soluble form of glycine C-methylcalix[4]resorcinarene (CR) by using different approaches of supramolecular and colloid chemistry. The first approach involves the ionization of hydroxyl groups of CR under the alkaline condition. The second is a supramolecular approach, which takes advantage of the high water solubility of N-methylglucamine. The third approach consists of the solubilization in surfactant solutions.