Measurement, correlation and thermodynamics of solubility of metronidazole in 2-(2-ethoxyethoxy)ethanol + water cosolvent mixtures at (298.15 to 333.15) K

The aim of present study was to measure and correlate the solubility of metronidazole (MTZ) in various 2-(2-ethoxyethoxy)ethanol + water mixtures from (2981.5 to 333.15) K using the shake flask method. The experimental solubilities of MTZ were correlated with Apelblat equation and Yalkowsky model. The percent of root mean square deviations (% RMSD) was obtained as (0.80 to 4.51)% for Apelblat equation and (1.42 to 11.57)% for Yalkowsky model. The mole fraction solubility of MTZ was observed to be the highest in pure 2-(2-ethoxyethoxy)ethanol (2.07 × 10− 2 at 298.15 K). The MTZ dissolution was observed as endothermic and spontaneous in all cosolvent mixtures. Based on current solubility data, MTZ has been considered as slightly soluble in pure water and soluble in pure 2-(2-ethoxyethoxy)ethanol.