SAR and DFI studies of supramolecular tetraammoniumplatinate + DNA matrix with UV/Vis spectrophotometry and physicochemical analysis at 298.15 K

DNA binding activity of bis(benzyldimethylalkylazaniumyl) tetrachloroplatinumdiuide supramolecular complexes (MBKs) was studied at 298.15 K with UV/Vis spectrophotometric and physicochemical methods. In UV/Vis spectrophotometric method, absorbance at λmax = 260 nm has inferred a hyperchromic effect for explaining intercalating nature of MBKs. DNA binding constant in spectrophotometric titrations for intercalating strength of complexes has shown stronger intercalating activities of MBK8 and MBK12. Density, sound velocity and refractive index of DNA have been studied before and after interaction with MBKs with their stronger interaction. Isentropic and apparent molal compressibilities have inferred that the supramolecular interactions cause distortion of DNA helix. The relative viscosity of DNA-MBKs inferred intercalation of MBKs with DNA due to an aromatic ring in MBKs. DFI relationship shows lowering in surface tension and increases in viscosity data of DNA-MBKs solution, and explained their interaction pattern. This DFI study explained their structure-activity relationship (SAR) as well as their anticancer nature.