Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5412780 | Journal of Molecular Liquids | 2011 | 6 Pages |
Abstract
The Knoevenagel condensation reaction of aromatic aldehydes with malononitrile or dimedone was investigated. Also, the three-component and one-pot synthesis of 2-amino-5-oxo-4-aryl-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives by condensing 4-hydroxycoumarin, aldehydes and malononitriles using a catalytic amount of 2-hydroxyethylammonium formate as an effective ionic liquid without using any additional co-catalyst under solvent-free conditions at room temperature is reported. Furthermore, the domino Knoevenagel condensation, conjugate addition, and cyclization for the preparation of tetrahydrobenzo[b]pyran, and spirooxindole derivatives in high atomic efficiency take place in excellent yields.
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Authors
H.R. Shaterian, M. Arman, F. Rigi,