Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5417651 | Journal of Molecular Structure: THEOCHEM | 2009 | 5 Pages |
Abstract
We investigated the structures and redox properties of copper-chelating cuprizone using DFT-B3LYP calculations to gain insights into its toxicity causing neurodegeneration similar to lesions in prion diseases. We found that the copper-cuprizone complex has redox potentials of the Cu(III)/Cu(II) couple that range from â0.05 to +0.98Â V (vs. normal hydrogen electrode), which are low enough to stabilize tri-valent copper(III) states. The resulting unusually high-valent copper(III) can be involved in cytotoxiciy to disrupt copper metabolism and/or to cause oxidative stress. This study on the redox behavior of copper-chelating cuprizone may provide not only an insight into its copper(III)-mediated toxicity but also a key to understanding for the pathogenesis of prion diseases.
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Authors
Norifumi Yamamoto, Kazuo Kuwata,