| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5420939 | Solid State Nuclear Magnetic Resonance | 2006 | 8 Pages |
Abstract
The 14N nuclear quadrupole double resonance spectra of different polymorphs of sulfanilamide, sulfadiazine, sulfamerazine and sulfamethazine have been measured and the 14N quadrupole coupling tensors have been determined. The obtained 14N spectra are compared with those of other sulfa drugs like sulfathiazole. It is shown that different polymorphs can be easily discriminated. The application of this technique for non-destructive analysis, polymorph determination and quality control in the production of pharmaceuticals is stressed.
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Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Robert Blinc, Janez Seliger, Aleksander ZidansËek, Veselko Žagar, Fani Milia, Hector Robert,