| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5426139 | Surface Science | 2007 | 5 Pages |
Abstract
A relationship between the fractal surface dimension of dissolving nanoparticles and their solubility has been derived showing that fractally rough nanoparticles are expected to exhibit significantly higher solubility than predicted from the classical Ostwald-Freundlich equation. The derived relationship estimates the latent solubility increase for a given material by manipulating the surface of the particles to be dissolved, and can thus be used for developing new strategies for improving the solubility of poorly soluble drug candidates.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Physical and Theoretical Chemistry
Authors
Albert Mihranyan, Maria Strømme,