Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5433699 | Journal of Controlled Release | 2017 | 7 Pages |
Poly(anhydride) are unstable and prone to hydrolytic degradation and depolymerisation via anhydride interchange. They are stored at â 20 °C, packed under inert atmosphere until use. We synthesized a new poly(anhydride) from ricinoleic (RA) and sebacic (SA) acid with alternating ester-anhydride structure that is stable at 25 °C for over 18 months. The copolymer is also stable in chloroform solution and under γ-irradiation. The polymer hydrolyses through anhydride cleavage lasting ~ 7 days to form oligoesters, which are stable for > 30 days. The release of gentamycin from the synthesized alternate polymer matrix is sustained compared to the random copolymer.
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