Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5434236 | Materials Science and Engineering: C | 2017 | 10 Pages |
â¢A multifunctional nanoplatform (GNRs@mSiO2-HA-RGD) was constructed.â¢It had a good photothermal effect and excellent drug loading capacity.â¢It also had pH-enzyme sensitive and NIR-triggered drug release properties.â¢It may be a new promising dual-targeted delivery system for chemo-photothermal therapy.
This work reports a multifunctional nanoplatform (GNRs@mSiO2-HA-RGD) by conjugating targeting ligand hyaluronic acid (HA) and RGD with mesoporous silica-coated gold nanorods (GNRs@mSiO2) for dual-targeted chemo-photothermal therapy. Doxorubicin hydrochloride (DOX) was used as the model drug to investigate the drug loading, in vitro drug release profiles and cell evaluation. The nanoplatform has demonstrated a good photothermal effect and excellent drug loading capacity of about 20.16%. It also had pH-enzyme sensitive and NIR-triggered drug release properties. Cellular uptake experiment results indicated that DOX-GNRs@mSiO2-HA-RGD can be dual-targeted to ovarian cancer cells via CD44 and integrin receptor mediated endocytosis pathway. Cytotoxicity experiments demonstrated that combined therapy exhibited a better therapy effect compared to that of single chemotherapy or photothermal therapy. Our study demonstrates that DOX-GNRs@mSiO2-HA-RGD may be a new promising dual-targeted delivery system for chemo-photothermal therapy.