Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5434258 | Materials Science and Engineering: C | 2017 | 9 Pages |
â¢PEGylated stereocomplex polylactide is developed as a promising coating of coronary stent.â¢The coating exhibits decreased fibrinogen adsorption, down-regulated platelet activation, and improved cytocompatibility.â¢The stereocomplex polylactide coating serves as a sustained drug reservoir.â¢The stereocomplex polylactide systems may be utilized as a promising platform for various biomedical applications.
Treatment of coronary heart disease by percutaneous coronary intervention (PCT) is usually limited to the high restenosis rate after implantation of bare-metal stent. To solve the problem, the coating of PEGylated stereocomplex poly(l-lactide) (PEGâcPLA) was utilized on the surface modification of stainless steel (SS) sheet. Specifically, the 3-aminopropyltriethoxysilane (APTES)-modified methoxy-poly(ethylene glycol)âpoly(d-lactide) (mPEGâPDLA) was grafted onto the surface of hydroxylated SS sheet through coupling reaction, and poly(l-lactide)âpoly(ethylene glycol)âpoly(l-lactide) (PLLAâPEGâPLLA) was coated onto the surface through stereocomplex interaction between DLA and LLA units. The increase of contact angle firstly confirmed the changes of surface composition and hydrophilicity for the PEGâscPLA-modified SS sheet. The decreased fibrinogen adsorption, down-regulated platelet activation, and improved adhesion of human umbilical vein endothelial cells (HUVECs) indicated the excellent biocompatibility of PEGâscPLA-modified SS sheet. In addition, the drug loading capability of SS sheet was greatly upregulated through the formation of scPLA coating on the surface, where fluorescein (FLU) was chosen as a model molecule. Overall, the surface modification of SS sheet with PEGâscPLA could enhance the comprehensive performances, such as biocompatibility and drug loading capability, demonstrating that PEGâscPLA is a promising coating of coronary stent for PCT.
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