| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5434331 | Materials Science and Engineering: C | 2017 | 8 Pages |
â¢Thin coating adjustmentâ¢Wrinkle structureâ¢Improved mechanical propertiesâ¢Progenitor cell differentiationâ¢Effective blood clotting cascade inhibition
The future and development of science are in interdisciplinary areas, such as biomedical engineering. Self-assembled structures, similar to stem cell niches, inhibit rapid cellular division processes and enable the capture of stem cells from blood flow. By modifying the surface topography and stiffness properties, progenitor cells were differentiated towards the formation of endothelial cell monolayers to effectively inhibit the coagulation cascade. Wrinkled material layers in the form of thin polymeric coatings were prepared. An optimized surface topography led to proper cell differentiation and influenced the appropriate formation of endothelial cell monolayers. Blood activation was decelerated by the formed endothelium.
