Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5434370 | Materials Science and Engineering: C | 2017 | 8 Pages |
â¢EμPAD offers many advantageous features such as facile approach, economical and have potential for commercialization.â¢Extensive development can be made for industrial translation of this fabricated device.â¢Ag@ Pd shell nanohybrids modified EμPAD showed wide linear range 1 - 300 ng/ml and low detection limit of 0.025 ng/l for alprazolam detection.â¢The developed sensor was tested in real time samples like urine and serum and found good correlation (99%).
We present results of the studies relating to fabrication of a microfluidic biosensor chip based on urchin like Ag@ Pd shell nano-hybrids that is capable of sensing alprazolam through electrochemical detection. Using this chip we demonstrate, with high reliability and in a time efficient manner, the detection of alprazolam present in buffer solutions at clinically relevant concentrations. Methylene blue (MB) was also doped as redox transition substance for sensing alprazolam. Nano-hybrids modified EμPAD showed wide linear range 1-300 ng/ml and low detection limit of 0.025 ng/l. Low detection limit can further enhance its suitability for forensic application. Nano-hybrids modified EμPAD was also employed for determination of drug in real samples such as human urine. Reported facile lab paper approach integrated with urchin like Ag@ Pd shell nano-hybrids could be well applied for the determination of serum metabolites.
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