Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5434531 | Materials Science and Engineering: C | 2017 | 10 Pages |
â¢Synthesis of multifunctional hybrid glass-ceramic/polymer scaffoldsâ¢Glass-ceramic scaffolds were coated with melanin, a natural derived polymerâ¢Scaffolds were loaded with ibuprofen using supercritical CO2 technologyâ¢Scaffolds exhibited an accelerated bioactivity and enhanced mechanical strengthâ¢Scaffolds showed a local drug delivery ability
In this work, hybrid melanin-coated bioactive glass-ceramic multifunctional scaffolds were developed and characterized in terms of mechanical strength, in vitro bioactivity in simulated body fluid (SBF) and ability to load ibuprofen. The coated scaffolds exhibited an accelerated bioactivity in comparison with the uncoated ones, being able of developing hydroxyapatite-like crystals after 7Â days soaking in simulated body fluid (SBF). Besides its positive influence on the scaffolds bioactivity, the melanin coating was able to enhance their mechanical properties, increasing the initial compressive strength by a factor of >Â 2.5. Furthermore, ibuprofen was successfully loaded on this coating, allowing a controlled drug release of the anti-inflammatory agent.