Inhibition of TNF-α sepsis of lipopolysaccharide induction using nano cerium oxide system

•Green synthesis of CeO2 NPs were achieved around the size of 37 nm with agglomerated spherical shape particles.•Further CeO2 NPs were subjected in vivo through tail nerves of rats to treat sepsis.•Finally the obtained results for concentration of CeO2 NPs and releasing of TNF-α were statistically significant at P < 0.05.

Nowadays sepsis was one of the major threatening issues all over the globe which majorly causes death in high rate. To treat sepsis only few reports have been proposed with the help of anti-oxidants. This manuscript stated that the grape is rich in anti-oxidant, with the help of anti-oxidant rich grape extract Cerium oxide nanoparticles (CeO2 NPs) were synthesized eco-friendly. Further the synthesized CeO2 NPs subjected for various characterization studies which resulted in 37 nm of size with agglomerated spherical shape particles. Further synthesized CeO2 NPs were subjected in vivo through tail nerves of rats to treat sepsis. CeO2 NPs stops the release TNF-α and tends to increase the ceria level in liver. Histopathological studies were performed and also reported. The obtained results were statistically significant with ANOVA LSD-Tukey's test were studied and reported in this manuscript.