Facilitation of transscleral drug delivery by drug loaded magnetic polymeric particles

A unique method was used to facilitate ocular drug delivery from periocular route by drug loaded magnetic sensitive particles. Injection of particles in periocular space along the eye axis followed by application of magnetic field in front of the eye would trigger the magnetic polymeric particles to move along the direction of magnetic force and reside against the outer surface of the sclera. This technique prevents removal of drug in the periocular space, observed in conventional transscleral drug delivery systems and hence higher amount of drug can enter the eye in a longer period of time. The experiments were performed by fresh human sclera and an experimental setup. Experimental setup was designed by side by side diffusion cell and hydrodynamic and thermal simulation of the posterior segment of the eye were applied. Magnetic polymeric particles were synthesized by alginate as a model polymer, iron oxide nanoparticles as a magnetic agent and diclofenac sodium as a model drug and characterized by SEM, TEM, DLS and FT-IR techniques. According to the SEM images, the size range of particles is around 60 to 800 nm. The results revealed that the cumulative drug transfer from magnetic sensitive particles across the sclera improves by 70% in the presence of magnetic field. The results of this research show promising method of drug delivery to use magnetic properties to facilitate drug delivery to the back of the eye.

Graphical abstractThis manuscript introduces a unique method to facilitate drug delivery to the back of the eye due to unmet need for treatment of the posterior segment of the eye diseases without intravitreal injection. It is one of the first, if not the first, to report application of magnetic nanoparticles to prevent drug clearance from back of the eye thereby helping to reach therapeutic amount of drug penetration to the eye. The results reveal enhanced drug transfer across the sclera in the presence of magnetic field and therefore a promising approach for the drug delivery.Download high-res image (80KB)Download full-size image