Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5434848 | Materials Science and Engineering: C | 2017 | 8 Pages |
â¢Salecan is a new water-soluble microbial polysaccharide.â¢Salecan-containing semi-IPN hydrogels were synthesized.â¢Effect of Salecan content on the properties of the hydrogels were studied.â¢The Salecan-based hydrogel was an effective vehicle for drug encapsulation/release.
Salecan is a new linear extracellular β-glucan. The unique structure and beneficial properties of Salecan makes it an appealing material in biomedical applications. In this work, novel drug devices based on Salecan in a hydrogel matrix of poly(N-(3-dimethylaminopropyl)acrylamide-co-acrylamide) (Salecan/PDA) were fabricated via free radical polymerization for controlled release of amoxicillin. It was demonstrated that amoxicillin was efficiently encapsulated into the developed hydrogels and released in a Salecan dose-dependent and pH-sensitive manner. Furthermore, cell toxicity and adhesion assays confirmed that these drug carriers were biocompatible. Altogether, this study opens a new avenue to fabricate hydrogel devices for controlled delivery of drug.