Simultaneous voltammetric analysis of anti-ulcer and D2-antagonist agents in binary mixture using redox sensor and their determination in human serum

•Voltammetric analysis of pantoprazole sodium and domperidone for the first time.•Poly (EBT)/PGE was used.•Investigation of the electro-deposition polymer using FTIR and SEM images.•High sensitivity and selectivity of the proposed method.•Application of the new sensor for determination of the binary mixture in synthetic mixtures and human serum.

Pencil graphite electrode was successfully modified with a thin film of poly (eriochrome black T) and applied for the sensitive and selective voltammetric simultaneous determination of pantoprazole sodium and domperidone in a binary mixture. The preparation and basic electrochemical behavior of poly (eriochrome black T) film on the Pencil graphite electrode were investigated. The modified electrode has exhibited very high electro-catalytic activity towards the cited mixture. The anodic peaks of the both species were well defined with enhanced oxidation peak currents. Under the optimum conditions, the linearity ranges were 0.4-55 × 10− 7 M and 0.1-34 × 10− 7 M for pantoprazole sodium and domperidone, respectively with detection limits of 0.12 × 10− 7 M and 0.04 × 10− 7 M for pantoprazole sodium and domperidone, respectively. The proposed sensor has been successfully applied in the analysis of pantoprazole sodium and domperidone in synthetic binary mixtures and human serum.

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