Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5434899 | Materials Science and Engineering: C | 2017 | 7 Pages |
â¢A pH and light-dual controlled cargo release system exhibiting AND logic is developed.â¢The delivery system can release the cargo in small potions by controlling the opening/closing of the gate.â¢The delivery system realizes the controlled release in zebrafish.
Recently, the controlled drug delivery system has become a potential platform for biomedical application. Herein, we developed a pH and light-dual controlled cargo release system exhibiting AND logic based on MCM-41 mesoporous silica nanoparticles, which was surface modified using β-cyclodextrin (β-CD) with imine bond and azobenzene derivative. The complex of β-CD and azobenzene derivative effectively blocked the cargo delivery in pH = 7.0 phosphate buffered saline (PBS) solution without 365 nm UV light irradiation. The cargo was fully released when both factors of acidic environment (pH = 5.0 PBS) and 365 nm UV light irradiation were satisfied, meanwhile only very little cargo was delivered if one factor was satisfied. The result also demonstrates that the opening/closing of the gate and the release of the cargo in small portions can be controlled.
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