MoS2/reduced graphene oxide nanocomposite for sensitive sensing of cysteamine in presence of uric acid in human plasma

•The hybrid nanocomposite composed of MoS2 nanosheets and reduced graphene oxide was fabricated by a facile and effective method.•The MoS2 nanosheets were uniformly anchored on the rGO framework with strong adhesion.•Glassy carbon electrodes modified with MoS2-rGO was used for electro-oxidation of cysteamine (CA) in presence of uric acid (UA).•The anodic peak current of CA at the surface of modified electrode is linear to its concentration ranges at 0.01 to 20 μM with a detection limit of 7 nM.•The proposed electrochemical sensor was used for determination of CA in human plasma.•The accuracy of the method was as excellent comparing with the obtained results using reference method.

A hybrid nanocomposite of MoS2 nanosheets and reduced graphene oxide (rGO) was fabricated by a facile and effective method. The morphology and structure of the nanocomposite (MoS2-rGO) were characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, electrochemical impedance spectroscopy and cyclic voltammetry. The MoS2 nanosheets were uniformly anchored on the rGO framework with strong adhesion. A glassy carbon electrode modified by drop-casting with MoS2-rGO was used for the electrochemical oxidation of cysteamine (CA) in the presence of uric acid (UA). Under optimum conditions, the anodic peak current of CA shows a linear relation with the CA concentration between 0.01 and 20 μM with a detection limit of 7 nM. The proposed electrochemical sensor was used for determination of CA in human plasma.