| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5435194 | Materials Science and Engineering: C | 2017 | 7 Pages |
â¢Folic acid-conjugated dextran stearate (DF) submicron particles to enhance RSV efficacy in lung cancersâ¢RSV-DF micelles exhibited an enhanced cellular uptake in A549 cells due to the folic acid-based receptor interactions.â¢RSV-DF showed an enhanced cellular apoptosis of cancer cells compared to that of free RSV.â¢RSV could be an interesting prospect to treat lung cancers.
In this study, we have aimed to prepare folic acid-conjugated dextran stearate (DF) polymeric micelles to target resveratrol in lung cancers. The polymeric micelle was nanosized and exhibited a controlled drug release pattern. The resveratrol (RSV)-loaded dextran stearate (RSV-DF) micelles exhibited an enhanced cellular uptake in A549 cells due to the folic acid-based receptor interactions. We have demonstrated that RSV-DF polymeric micelles retain the cytotoxic and metabolic effects of RSV on A549 cancer cells with potencies similar to that of the free compound. Furthermore, RSV-DF showed an enhanced cellular apoptosis of cancer cells compared to that of free RSV. We have found that apoptosis induced by RSV-DF was associated with the higher expression of p53, caspase-3, and BAX than the free RSV. The higher level of BAX and caspase-3 further indicates the involvement of mitochondria-dependent apoptosis in the anticancer efficacy of formulations. Based on these results, it can be concluded that natural compound like RSV could be an interesting prospect to treat lung cancers and the fact that folic acid-conjugated dextran stearate could be a potential carrier to deliver the drug in the cancer cells.
