Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5437761 | Ceramics International | 2017 | 8 Pages |
Abstract
Ceramic-metal composite materials, namely cermets, are provided with characteristics of both ceramic and metal. Herein, for the first time bio-cermets based on β-tricalcium phosphate (β-TCP) bioceramic with biodegradable iron being reinforcement phase, were fabricated using the powder metallurgic method. The phase composition, microstructure, mechanical properties and in vitro cell behaviors of bio-cermets were investigated. The results revealed that atomic diffusion occurred between the iron and β-TCP matrix during the sintering process. The bio-cermets attained remarkable increase in fracture toughness (1.16-1.55 MPa m1/2) compared to the β-TCP bioceramic (0.54 MPa m1/2). The bio-cermets with 10 vol% iron showed the highest compressive strength (640 MPa), significantly higher than that of plain β-TCP bioceramic (285 MPa). The in vitro cell behaviors test indicated that the bio-cermets did not showed any sign of toxicity; the iron ions released from bio-cermets up-regulated bone-related gene expression of bone mesenchymal stem cells. The bio-cermets developed in this study represent potential bone substitutes for application in the load-bearing bone defects.
Related Topics
Physical Sciences and Engineering
Materials Science
Ceramics and Composites
Authors
Fupo He, Guowen Qian, Weiwei Ren, Jinhuan Ke, Peirong Fan, Xuetao Shi, Yanling Cheng, Shanghua Wu, Xin Deng, Jiandong Ye,