Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5449075 | Optics Communications | 2017 | 5 Pages |
Abstract
Although the diffraction limit still restricts their lateral resolution, conventional wide-field Raman imaging techniques offer fast imaging speeds compared with scanning schemes. To extend the lateral resolution of wide-field Raman microscopy using filters, standing-wave illumination technique is used, and an improvement of lateral resolution by a factor of more than two is achieved. Specifically, functionalized surface enhanced Raman scattering nanoparticles are employed to strengthen the desired scattering signals to label cell membranes. This wide-field Raman imaging technique affords various significant opportunities in the biological applications.
Related Topics
Physical Sciences and Engineering
Materials Science
Electronic, Optical and Magnetic Materials
Authors
Houkai Chen, Siqi Wang, Yuquan Zhang, Yong Yang, Hui Fang, Siwei Zhu, Xiaocong Yuan,