Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5449998 | Physica E: Low-dimensional Systems and Nanostructures | 2017 | 4 Pages |
Abstract
The carbon nanotubes field effect transistor (CNTFET) based DNA sensor was developed, in this paper, for detection of influenza A virus DNA. Number of factors that influence the output signal and analytical results were investigated. The initial probe DNA, decides the available DNA strands on CNTs, was 10 µM. The hybridization time for defined single helix was 120 min. The hybridization temperature was set at 30 °C to get a net change in drain current of the DNA sensor without altering properties of any biological compounds. The response time of the DNA sensor was less than one minute with a high reproducibility. In addition, the DNA sensor has a wide linear detection range from 1 pM to 10 nM, and a very low detection limit of 1 pM. Finally, after 7-month storage in 7.4 pH buffer, the output signal of DNA sensor recovered 97%.
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Authors
Thi Luyen Tran, Thi Thuy Nguyen, Thi Thu Huyen Tran, Van Tuan Chu, Quang Thinh Tran, Anh Tuan Mai,