| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5463287 | Materials Letters | 2017 | 4 Pages |
Abstract
Cellulose-based nanoparticles have very fine application foreground in drug delivery. Herein, a new cellulose-hydrophobic polymer hybrid nanoparticle (CE-g-PMMA NPs) with low polydispersity index has been builted by an easy method. The obtained nanoparticles with 2029Â wt% of PMMA possessed appropriate size (â¼120Â nm), high drug loading efficiency (â¼20Â wt% BA) and a slow drug release rate. The CE-g-PMMA NPs not only showed excellent biocompatibility, More important, compared to the free betulinic acid (BA), the BA-loaded CE-g-PMMA NPs significantly improved the cellular cytotoxicity and reduced the risk of side-effect. This cellulose-based “green nanoparticles” showed highly potential for hydrophobic anti-cancer drug delivery.
Related Topics
Physical Sciences and Engineering
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Authors
Lin Dai, Chuan-Ling Si,