| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5466456 | Thin Solid Films | 2016 | 6 Pages |
Abstract
For implant materials, bioactivity is an important factor in achieving favorable osseointegration. A β-type Ti-25Nb-8Sn alloy with a low Young's modulus is used in this study. In order to improve the bioactivity of Ti-25Nb-8Sn alloy, the surface of the specimens used in this study was modified by immobilizing a RGD peptide. After alkaline treatment, the surface of the Ti-25Nb-8Sn substrate exhibited a micro-network structure. XRD analysis found that this structure was sodium titanate (Na2Ti5O11). FTIR analysis confirmed that the surface of the micro-networked Ti-25Nb-8Sn alloy can be grafted with RGD peptide using covalent binding. The MTT activity assay showed that there is higher bioactivity on the surface of the RGD peptide-grafted Ti-25Nb-8Sn, and SEM observations showed that the presence of RGD on the surface of the alloy could improve cell adhesion. In this study, the biomimetic modification of Ti-25Nb-8Sn alloy using RGD peptide has been demonstrated to produce superior biocompatibility.
Related Topics
Physical Sciences and Engineering
Materials Science
Nanotechnology
Authors
Shih-Kuang Hsu, Wen-Fu Ho, Shih-Ching Wu, Yun-Shan Chen, Hsueh-Chuan Hsu,