Modeling and Additive Manufacturing of Biomimetic Heterogeneous Scaffold

In this paper, a feature-based bio-CAD modeling of three-dimensional tissue scaffolds by considering spatial distribution of biologically active materials is presented for biomanufacturing and tissue engineering applications. Proposed model is based on uniform distribution of bio-active particles in different regions of scaffold, which is constrained by geometrical and biological features. The proposed method was integrated with a recently developed method of multi-material additive manufacturing of hydrogel structures, for bio-additive manufacturing of the heterogeneous scaffolds. 3D bioprinted heterogeneous scaffolds were provided as an example for physical implementation of developed algorithm to validate the model.