Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5477638 | Journal of Environmental Radioactivity | 2017 | 5 Pages |
Abstract
Both cell types showed distinct ability for apoptosis as proven with camptothecin. The addition of “cold” iodine from 1 to 15 μg/ml without irradiation (“negative control”) did not change the response in both cell types. Plausibly, the radio-sensitivity of both cell types did increase markedly with increasing radiation dose but the radiation effect is diminished if iodine is added to the thyroid cells beforehand. The DNA-damage in thyroid cells after addition of cold iodine is reduced by a factor of 2-3. The skin cells did not show an significant change of radio-sensitivity depending on the presence of cold iodine. Elementary iodine possibly acts as a radical scavenger and thus markedly reduces the secondary radiation damage caused by the formation of cytotoxic radicals. This intrinsic radioprotective effect of iodine is seen only in cells with NIS.
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Authors
F. Sudbrock, A. Herrmann, T. Fischer, B. Zimmermanns, W. Baus, A. Drzezga, K. Schomäcker,