Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5485646 | Ultrasound in Medicine & Biology | 2017 | 10 Pages |
Abstract
Interstitial fluid pressure (IFP) in rats with breast cancer xenografts was non-invasively estimated using subharmonic-aided pressure estimation (SHAPE) versus an invasive pressure monitor. Moreover, monitoring of IFP changes after chemotherapy was assessed. Eighty-nine rats (calibration n = 25, treatment n = 64) were injected with 5 Ã 106 breast cancer cells (MDA-MB-231). Radiofrequency signals were acquired (39 rats successfully imaged) with a Sonix RP scanner (BK Ultrasound, Richmond, BC, Canada) using a linear array (L9-4, transmit/receive: 8/4 MHz) after administration of Definity (Lantheus Medical Imaging, North Billerica, MA, USA; 180 μL/kg) and compared with readings from an invasive pressure monitor (Stryker, Berkshire, UK). An inverse linear relationship was established between tumor IFP and SHAPE (y = â1.06x + 28.27, r = â0.69, p = 0.01) in the calibration group. Use of this relationship in the treatment group resulted in r = 0.74 (p < 0.05) between measured (pressure monitor) and SHAPE-estimated IFP (average error: 6.24 mmHg). No significant before/after differences were observed with respect to paclitaxel treatment (5 mg/kg, Mayne Pharma, Paramus, NJ, USA) with either method (p â¥Â 0.15).
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Authors
Valgerdur G. Halldorsdottir, Jaydev K. Dave, Andrew Marshall, Anya I. Forsberg, Traci B. Fox, John R. Eisenbrey, Priscilla Machado, Ji-Bin Liu, Daniel A. Merton, Flemming Forsberg,