Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5497027 | Physics Letters A | 2016 | 5 Pages |
Abstract
We determine, by using a tight-binding model Hamiltonian, the characteristic current-voltage (IxV) curves of a 5-methylated cytosine single strand poly-GC DNA-like finite segment, considering the methyl groups attached laterally to a random fraction of the cytosine basis. Striking, we found that the methylation significantly impacts the ohmic resistance (R) of the DNA-like segments, indicating that measurements of R can be used as a biosensor tool to probe the presence of anomalous methylation.
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Authors
F.A.B.F. de Moura, M.L. Lyra, M.L. de Almeida, G.S. Ourique, U.L. Fulco, E.L. Albuquerque,