Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5497945 | Applied Radiation and Isotopes | 2017 | 7 Pages |
Abstract
The objective of the present work is to formulate 170Tm-EDTMP using an in-house freeze-dried EDTMP kit and evaluate its potential as a bone pain palliation agent. Patient dose of 170Tm-EDTMP was prepared with high radiochemical purity using the lyophilized kit at room temperature within 15Â min. Pre-clinical evaluation in normal Wistar rats revealed selective skeletal accumulation with extended retention. Preliminary clinical investigation in 8 patients with disseminated skeletal metastases exhibited selective uptake in the bone and retention therein for a long duration.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Tapas Das, Ajit Shinto, Koramadai K. Kamaleshwaran, Haladhar D. Sarma, Sahiralam Khan Mohammed, Arpit Mitra, Sangita Lad, M.G.R. Rajan, Sharmila Banerjee,